慢性丙型肝炎时贮脂细胞的定量研究

Quantitative study on fat-storing cells in the liver with chronic hepatitis C

应用免疫组化等方法，对慢性迁延性丙型肝炎肝组织中呈结蛋白阳性的贮脂细胞进行了定量的研究。结果显示：结蛋白阳性的细胞数量与同阶段的乙型肝炎相比显著减少；电镜观察可见肝窦中有较多的枯否细胞，肝细胞间隙及窦周胶原纤维的沉积。我们认为，在丙型肝炎早期纤维化中，贮脂细胞可能并非主要导致纤维化的效应细胞。

Quantitative study on desmin-positive fat-storing cells (FSC) by immunohis-tochemistry was carried out. It was demonstrated that FSC were predominantlv decreased in chronic persistent hepatitis C compared with chronic persistent hepatitis B. Under electron microscopy promient increase of Kupffer cells were noted in the hepatic sinuses and collagen fibers were frequently deposited in the Disse spaces or between the liver cells. It was suggested that in the development of fibrosis of hepatitis C FSC might not play an important role as found in the cases with hepatitis B.