78例病毒性肝炎血浆内毒素检测的临床分析

The clinical analyses of the detecting of the plasma endotoxin of 78 cases ill with viral hepatitis

本文采用鲎试验对78例病毒性肝炎和20例健康人血浆内毒素定量检测，结果急性肝炎为70．14±30．40ng／L；慢性肝炎为105．03±66．03ng／L；重症肝炎119．07±66.44ng／L；原发性肝癌为139±35．59ng／L；对照组5．25±2．90ng／L．4组肝炎与对照组相比均有显著差异（P＜0．01）。78例肝炎患者ALT和血清脸红素（SB），重症肝炎和肝癌组血浆内毒素水平与ALT、SB增高一致．ALT分别为174．89±99.60u／L和134．30±63.75u／L；SB分别为145．36±51．95mmol／L和102．53±50．54mmol／L，其他两组与内毒素关系不大。表明肝炎患者血浆内毒素水平均有不同程度增高，对判断病情和预后有一定意义。

The quantitative determinations of the plasma endotoxin levels were made by usinS the quantitative endotoxin assay of limulus amoebocyte lysate test in 78 cases ill with viral hepatitis and 20 cases who were not hepatopaths as control group. The results showed that the endotoxin concentration in the patients ill with acute hepatitis was 70. 14±30.40ng/L;105. 03±66. 03ng/L in chronic hepatitis; 119.07±66. 44ng/L in severe hepatitis; 139±35. 59ng/L in primary hepatic carcinoma and 5. 25±2. 90ng/L in normal individuals in the control proup. In comparison with the control group,there vvere remarkable differences among the four groups of the patients ill with hepatitis respectively (P<0. 01). ALT and SB (serum bilirubin) of 78 cases ill with hepatitis,the plasma endotoxin level of severe hepatitis and hepatic carcinoma were the same with the increase of ALT and SB. ALT were 174. 89±96. 60u/L and 134.30± 63. 75u/L respectively;SB were 145. 36±5. 95mmol/L and 102.53±50. 54mmol/L respectively. The other two groups had no much relations with endotoxin. The results show that all the plasma endotoxin levels in the patients ill with hepatitis increase in some degree and this condition has a certain significance in diagnosing the patient's condition and in prognosis.