补体对免疫沉淀的抑制作用与小儿肾脏疾病的关系

The relation between inhibition of immune precipitation by complement and the child nephropathy

以辣根过氧化物酶（PO）和抗-PO作为免疫沉淀中的抗原和抗体，用光电比色法，对78例小儿肾脏疾病血清补体对免疫沉淀的抑制作用（IIPC）进行了研究，并同时检测补体成分C3、C4。结果，正常对照IIPCOD值为0．505±0．085，急性肾小球肾炎（0．137±0．108）显著降低（P＜0．001）；慢性肾小球肾炎（0．470±0．053）改变不明显（P＞0．05）；肾病综合征（0．401±0．038）明显低下（P＜0．05）。IIPC低下的发生率依次为急性肾小球肾炎（83％）、肾病综合征（43％）、慢性肾小球肾炎（32％）。表明小儿肾小球疾病时IIPC大多降低并与疾病的活动性有关。因此认为IIPC低下在肾脏病的发生和发展中起一定作用。

Using peroxidase (PO) and anti-PO as an antigen and antibody of immune precipitation,the inhibition of immune precipitation by complement (IIPC ) of 78 cases ill with the child nephropathy was studied by photoelectric colormetry. At the same time, C3 and C4 of serum were determined. The results showed that in comparison with the OD value of IIPC in the control group (0．505±0．85) )the OD value of IIPC in the patients ill with acute glomerulonephritis (GN) (0．137±0．108) remarkably lowered (P＜0．001) ;that of the chronic GN (0．470±0．053) did not obviously change (P＞0．05); that of nephrotic syndrome (0．401 ±0．038) was obviously lower (P＜0．05). The rates of lower IIPC in acute GN, in nephrotic syndrome and in chronic GN were 83%, 43% and 32% successively. These results suggest that the most increasing of IIPC with the child glomerulopathy liave relations with the nephropathic activity. So it is considered that the lower IIPC plays a certain role in the nephropathic occurrence and advance.