肾脏病患者血浆纤维连接蛋白检测分析

Analysis of the detecting of the levels of plasma fibronectin in the patients ill with nephropathy

本文采用单向琼脂扩散法对56例肾脏病患者血浆纤维连接蛋白（Fn）进行了定量检测。结果，正常对照组血浆Fn水平为2．94±0．60g／L，19例急性肾小球肾炎为1．90±0．79g／L；21例慢性肾小球肾炎为1．42±0．51g／L；16例肾病综合征为2．60±0．61g／L。与正常对照组相比，急、慢性肾小球肾炎均显著降低（P＜0．01，P＜0．001）；肾病综合征Fn无明显改变（P＞0．05）。表明急、慢性肾小球肾炎血浆Fn水平降低与Fn参与免疫复合物形成和清除及损伤组织的修复有关。

The levels of plasma fibronection (Fn) in the 56 cases ill with nephropathy were quantitatively detected by agar single diffusion technique. The results showed that the levels of plasma Fn were 2．94±0． 60g/L, 1． 90±0．79g/L, 1．42±0．51g/L and 2．60±0．61g/L in themormal control group,in the 19 cases il with acute glomerulonephritis (GN),in the 21 cases ill with chronic GN, and in the 16 cases ill with nephrotic syndrome respectively. In comparison with the normal control group, the concertrations of both the acute and chronic GN were significantly decreased (P＜0．01, P＜0．001); the level of Fn of nephrotic syndrome did not obviously change (＞0．05). The results indicate that the decrease in concentrations of the plasma Fn in both acute and chronic GN have relations with Fn joining in the forming,cleaning of immune complex (IC) and the repairing of injured tissues.