利多卡因对四种惊厥的影响

FFECT OF LIDOCAINE ON FOUR TYPES OF SEIZURE

用外周给药法观察了利多卡因（ｌｉｄｏｃａｉｎｅ）对四种惊厥发作的影响。利多卡因静脉注射（ｉｖ）０．４，０．８，１．６ｍｇ·ｋｇ￣（－１）可显著地和剂量相关地减弱或消除大鼠听源性惊厥（ａｕｄｉｏｇｅｎｉｃｓｒｅｉｓｕｒｅ，ＡＳ）。腹腔注射（ｉｐ）利多卡因也有同样效应。在ＡＳ反应阴性大鼠上，利多卡因（１．６ｍｇ·ｋｇ￣（－１））可对抗士的宁（ｓｔｒｙｃｈｎｉｎｃ）所诱发的ＡＳ，但对大鼠士的宁惊厥却略有易化作用。利多卡因在（ｉｐ）０．８ｍｇ·ｋｇ（－１）时可延缓小鼠异烟肼（ｉｓｏｎｉａｚｉｄｃ）发作潜伏期和死亡期，但在ｉｐ，０．４，１．０ｍｇ·ｋｇ（－１）时不能对抗小鼠士的宁惊厥。本文对利多卡因抗惊厥作用的膜稳定机制进行了讨论。

The effect of lidocaine on four types of seizure was observed by means of systemic ad-ministration,The lidocaine of intravenous injection(iv,0.4,0.8,1.6mg·kg￣(-1)) was able to reduceor to abolish the audiogenic seizures (AS) in rats markedly and doserelatively. Similar action was observed when lidocaine was administrated intraperioneally (ip)in rats. In those rats their AS re-sponse was negative. The lidocaine(ip),1.6 mg·kg￣(-1) was able to antagOnize the strychnine-induced AS,but lidocaine facilitated the strychnine-induced seizure in rats a little. Lidocaine(ip,0.8mg· kg￣(-10)increased the latency of isoniazide-induced seiazure and delayed the lethality fol-lowing seizure in mice. LidOcaine(ip,0.4,1.6mrkg￣(-1)) can nOt antagonize strychnine-seizurein mice. The membrane stabilizing mechanism of anticon vulsantation of lidocaine was discussedin the present paper.