内毒素对实验性急性肝功能不全的作用

The action of endotoxin on acute hepatic insufficiency

本文对大肠杆菌内毒素在半乳糖胺引起急性肝功能不全中的作用进行了研究。实验结果表明,内毒素加重半乳糖胺所致的肝细胞坏死,使大鼠血浆尿素氮、胆红素水平升高,凝血酶原时间延长,嗜睡时间提前与昏迷加重。经血浆、脑匀浆游离氨基酸分析提示,内毒素可使脑组织牛磺酸水平增高。上述结果表明,内毒素血症是诱发急性肝功能不全发生发展的重要因素。

The effects of E. coli endotoxin on acute hepatic insufficiency induced by galactosamine were studied. Results indicated that endotoxin exhibited significant effects of promoting the nerosis of hepatocyte, prolonging prothrombin time, elevating the serum levels of billrubin and urea nitrogen on acute hepatic insufficiency in rats induced by galactosamtne. Lethargy and coma in the latter rats treated with endotoxin occured more quickly and more seriously than those in the controls, but no significant difference of amino acids in plasma and brain was found except for taurine which showed a significant increase in brain. These results suggest that endotoxin is an important factor in the development and progress of acute hepatic insufficiency.