急性脑梗塞患者血浆TXB_2、6-Keto-PGF_(1α)含量的变化

The changes serum thromboxane B_2 and 6-Keto-PGF_(1α) in patients with acute cerebral infarction

本文报告了31例健康人血浆中TXB_2与6-Keto-PGF_(1α)的测定结果。并对51例急性脑梗塞患者血浆中TXB_2、6-Keto-PgF_(1α)进行了测定,结果表明急梗组病人较对照组血浆TXB_2明显增高P<0.01);而病入血浆中6-Keto-PGF_(1α)与对照组相比也有明显差异(P<0.01),TXB_2/6-Keto-PGF_(1α)比值增大。40—50岁患者,血浆TXB_2含量明显高于同龄对照组(P<0.01),而6-Keto-PGF_(1α)含量组间差异不明显。测定结果提示,TXB_2/6-Keto-PGF_(1α)失衡与脑血栓性梗塞发生有关;在急性脑梗塞发病机制中可能由于TXA_2生成增多,血小板活性增强所致。

The peripheral venous plasma levels of TXB_2 and 6-Keto-PGF_(1α) were determined by radioimmunoassay in 31 control subjectsandand 51 patients with acute cerebral infarction(ACI).In ACI patients, the plasma TXB_2 levels were significantly higher than those in control subjects (P<0.01). In ACI patients, the plasma 6-Keto-PGF_(1α) levels were significantly lower than those in control subjects(P<0.01). Therefore, the TXB_2/6-Keto-PGF_(1α) ratios was significantly increased.A significant increase of TXB_2 was found in patients with an age range from 40-50. There was no significant difference in 6-Keto-PGF_(1α) levels within this age group. Our results may be considered to show that a disturbed balance between TXB_2 and PGI_2 is associated with the development of cerebral thrombotic infarction. These elevations of TXB_2 are consistent with a role for increased platelet activation in the pathogenesis of ACI.