静脉内注射纳洛酮对家兔内毒素性双相热和正常体温的影响

The effects of intravenous administration of naloxone on the biphasic fever induced by endotoxin and on the normal body temperature in rabbits

用封闭群新西兰白兔28只,观察了阿片受体阻断剂纳洛酮对内毒素性双相热和正常体温的影响。结果表明,预先静脉内给予纳洛酮对较大剂量内毒素引起的双相热没有显著影响,但纳洛酮单独给药,能够使正常体温下降达0.46℃。据此作者推论;内源性阿片肽在较大剂量内毒素性双相热的发生机制中不起重要作用,而对于维持正常体温则可能是必需的。

With 28 of new zealand rabbits, following observations were carried out: effects of intravnnous admiaistration of naloxone, an antagonist of opiate receptor, (1) on the biphasie fever induced by endotoxin; (2) on the body temperature of the normal rabbits. The results obtained indicated: the biphasic fever, which was induced by endotoxin at a dose of 5μg/kg was not changed significantly by the pretreatment of naloxone. However, the body temperature of normal rabbit was decreased to-0.46℃ following the administration of naloxone. The authors suggest that the endogenous opioid peptides are not necessary in the pathogenesis of the endotoxin biphasic fever. However, they play probably some role in the maintaining of physiological body temperature of the rabbit.