鼻咽癌患者血清β_2-微球蛋白含量的观察

Observation of serum β_2-microglobulin content in nasopharyngeal carcinoma (NPC) patients

本文对53例未经治疗鼻咽癌患者,血清β_2-MG含量测定,平均值为3.83±3.7μg/ml((?)+SD),另45例经过临床治疗症状改善者,血清β_2-MG平均为1.50±0.81μg/ml((?)±SD),两组之间有明显差异(P<0.01)。鼻咽癌及Hela细胞在体外培养过程中,亦见随着细胞的增殖可以不断合成β_2-MG,故可以推测鼻咽癌病人血清中β_2-MG的升高,可能来源于癌细胞的合成和释放,但非特异性。

This paper reports the results of determinations for 53 cases of untreated NPC patients by measurement of serum β_2-MG. The average is 3.83±3.71μg/ml ((?)±SD). In other 54 cases of relivf, according to the treatment, the level of serum β_2-MG is 1.5±0.81μg/ml ((?)±SD). There is significant difference between the two groups (P<0.01). During cultivation in vitro the NPC and Hela cell can be seen. The synthesis of β_2-MG is following propagation of these cells. So we suppose mat the serum β_2-MG Increase of NPC patients may be origented from the cancar cell's synthesis and their release, but this is non specific.