心交感神经反射在阻断冠脉血流后血液流变学变化中的作用

Role of cardiac-cardiac sympathetic reflex in the hemorheologic changes caused by acute coronary occlusion

本实验在21只狗身上观察了阻断冠脉血流后缺血区局部静脉血与体循环静脉血流变特性的变化及心交感神经反射在这一变化中的作用。主要结果如下:1.心肌缺血时血液流变学出现明显异常变化,且缺血区局部静脉血高切变率下全血粘度变化大于体循环静脉血;2.阻断冠脉血流后用利多卡因浸润缺血区心肌,可使心肌缺血时体循环血液流变学变化明显减轻,但缺血区局部静脉血高切变率下全血粘度仍明显升高;3.阻断冠脉前切除双侧星状神经节对心肌缺血时血液流变学变化无明显影响。上述结果提示,阻断冠脉血流后起源于缺血区内的传入神经活动增强是诱发血液流变学变化的重要因素。

The changes in flow properties of blood draining-from ischemic area and from systemic circulation causad by acute coronary occlusion were studied in 21 anesthe- tized open-chest dogs and the role of cardiac-cardiac sympathetic reflex in these changes was analysed. The main results obtained were as in the following: 1. The obvious hemorhoblogic changes were detected at the early phase of myocardial ischemia and the more significant change in high shear viscosity of whole blood was observed in coronary venous blood draining from ischemic area; 2. Topical application of lidocaine to the ischemic area of the heart virtually abolished the hemorheologie changes in systemic venous blood caused by coronary occlnsion, but had no significant effect on the change in high shear viscosity of blood draining from the ischemic area; 3. Bilateral section of stellate ganglia had no effect on the changes in hemorheologe following coronary occlusion. The results mentioned above suggested that increased activity of cardiac sympathetic nerves which originated from ischemic area had an important role in causing hemorheologic changes following coronary occlusion.