慢性乙型肝炎患者T淋巴细胞亚群及可溶性白细胞介素一2受体的研究

CLINICAL STUDIES ONT CELL SUBPOPULATION AND SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR IN PATIENTS WITH CHRONIC HEPATITIS B

应用ＡＰＡＡＰ免疫酶桥法及双抗体夹心ＥＬＩＳＡ法测定１５１例慢性乙型肝炎患者外周血Ｔ淋巴细胞亚群和血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）。结果显示，慢乙肝患者ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８比值明显降低，ＣＤ８则明显升高。表明慢乙肝患者体内存在Ｔ淋巴细胞比例失衡，细胞免疫调控功能紊乱。慢乙肝患者血清ＳＩＬ－２Ｒ水平均显著升高，其中以慢重肝和慢活肝升高最为显著，提示ＳＩＬ－２Ｒ水平高低能反映机体免疫功能状态及肝细胞损伤程度。Ｔ细胞亚群和ＳＩＬ－２Ｒ联合检测对慢乙肝患者病值变化、临床诊断分型及预后判断有重要价值。

The distribution of T cell subpopulation and the concentration of serum soluble interleukin-2(SIL-2R) receptor were determined in 151 patients with chronic hepalitis B by an APAAP immune-bridge assay and a double-antibodies ELISA. The date showed that the number of CD3, CD4 and the ratio of CD4 to CD8 were significantly lower, and the number of CD8 was significantly increased in patients with chronic hepatitis B, and indicated the disorders of T lymphatic cell proportion and cell immune adjustment function in these patients.The level of SIL-2R was also significantly higher in all patients, especially in patients with chronic fulminant hepatitis or chronic active hepatitis, and reflected on the conditions of human immune function and hepatic cell lesions. This present data suggest that the combined analyses of T cell subpopulation and SIL-2R may be an important value in clinical type and prognosis of liver diseases in patients with chronic hepatitis B.