α－羟丁酸脱氢酶对急性心肌梗塞的诊断意义

DIAGNOSTIC SIGNIFICANCE OF SERUM α-HBD IN ACUTE MYOCARDIAL INFARCTION

采用速率法生化技术测定正常人及急性心肌梗塞（ＡＭＩ）病人发病后不同时期血清α－羟丁酸脱氢酶（α－ＨＢＤ），发现ＡＭＩ发生后６小时α－ＨＢＤ开始持续升高，至４８小时达到高峰，后逐渐下降，但仍可维持１７天而与正常对照组有显著差异（Ｐ＜０．０１）。α－ＨＢＤ与同步测定的血清肌酸磷酸激酶（ＣＰＫ）呈正相关并随梗塞面积的增大而升高显著。结果表明，α－ＨＢＤ对ＡＭＩ的诊断、病变损伤程度的估计都有帮助，是诊断ＡＭＩ的一项重要指标。

In this article, the diagnostic value of serum alpha-hydroxybutyrate dehydrogenase(α-HBD) was studied in 28 patients with acute myocardial infarction(AMI) in whom serum α-HBD activities were determined respectively by kinetic rate biochemistric technique in different periods during an infarction. The results showed that α-HBD levels began rising 6hours after infarction, peaked up to 10 times normal values at approximately 48 hours, and remained in the seurm for 2 to 3 weeks. On the 17th day after infarction, when the other myocardial enzymes had returned to normal, serum α-HBD was presented in 19(70%) of 27patients and its average vaules were higher than those in the normal group(P<0.01). Serum α-HBD levels were significantly elevated with the broadening of infarct size and the occurence of sever complications. The study indicated that serum α-HBD plays important roles in the diagnosis, prognosis and the estimation of infarct size in AMI.