NIDDM血浆载脂蛋白A_1、B_(100)、C_(Ⅱ)、C_(Ⅲ)的研究

On Levels of Plasma Apolipoproteins A_1 ,B_(100), C_Ⅰand C_Ⅱ in NIDDM

对78例非胰岛素依赖型糖尿病(NIDDM)及56例正常人的血脂(TC、TG、HDL、HDL_ 2、HDL_3、ApoA_1、B_(100)、C_(Ⅱ)、C_(Ⅲ))的水平进行测定分析.结果表明;NIDDM血脂代谢明显异常,表现为:TC、TG、LDL、ApoB_(100)、C_(Ⅱ)水平显著性升高,而HDL、HDL_2、HDL_3、ApoA_1、C_Ⅰ水平显著性下降.作者认为:NIDDM血脂代谢紊乱是其伴有动脉粥样硬化的重要因素;NIDDM的载脂蛋白水平不受血糖及降糖药物的影响,具有更大的临床应用价值.

Plasma lipids (TG,TC,LDL,HDL,HDL2,HDL3,ApoA1, ,ApoB100,ApoC1, and ApoC1) were determined in 78 cases of NIDDM and 56 normal controls. The result showed that in cases of NIDDM .levels of plasma TG,TC,LDL, ApoB100,and ApoC1 were significantly raised .whereas levels of HDL,HDL2,HDL3,ApoA1 ApoC1 were below normal. The authors claim that an alteration in apolipoproteins may contribute to the development of atherosclerosis in NIDDM. The apolipoprotein levels,being not influenced by plasma glucose and hypoglycemic drugs,may be of more importance clinically.