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3岁以下婴幼儿肾病综合征的研究 被引量:2

Nephrotic syndrome in Infants Below 3-year-old
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摘要 3岁以下婴幼儿肾病综合征(简称婴幼儿肾病)在儿科肾病综合征中有其一定的特殊性。本组资料观察了26例婴幼儿肾病,发现婴幼儿肾病临床上以肾炎性肾病为主,病理上以非微小病变性肾病为主;约88%对激素治疗不敏感,而且对其它免疫抑制剂缓解率也低。本组资料表明婴幼儿肾病总缓解率仅为50%,治疗比较困难,预后差。 Primary nephrotic syndrome (NS) in 26 infant patients below 3 years old was analyzed. The data showed that in these patients, the clinical feature was characterized by, nephritic nephrosis with hostopathologic changes. Most of the patients in this series did not respond to corticosteroid(the ratio of corticosteroid response being only 12%)and also poorly responded to other immunosuppreants, These results suggest that the total remission rate of infant NS was only 50%.Its clinical treatment is difficult and the prognosis of these patients is poor.
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 1995年第2期326-327,共2页 Journal of Nanjing Medical University(Natural Sciences)
关键词 肾病综合征 治疗 婴幼儿 nephrotic syndrome therapy infant
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  • 1胡亚美,诸福堂.实用儿科学[M].7版.北京:人民卫生出版社,2002:1174
  • 2Ruf RG,LichtenbergerA, Karle SM,et al. Patients with mutations in NPHS2(pedocin)do not respond to standard steroid treatment of nephrotic syndrome[J]..l Am Soc Nephrol, 2004, 15(3):722-732.
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  • 5Okada H,Kikuta T, Inoue T, et al. Dexamethasone induces connective t issue growth factor expression in renal tubular epithelial cells in mouse strain- specificmanner[J].Am J Pathol, 2006, 18 (3) : 737-747.
  • 6Gulati S, Kher V. Intravenous pulse cyclophosphamide- -a new regime f or steroid resist ant focal segment al glom erulosclerosis[J].Indian Pediatr, 2000, 37(2): 141-148.
  • 7黄文彦,陈荣华,甘卫华,胡明昌,黄松明,丁桂霞,姜新猷.环磷酰胺静脉冲击联合泼尼松治疗儿童激素耐药性肾病综合征疗效分析[J].中华儿科杂志,2001,39(12):722-725. 被引量:18
  • 8中华医学会儿科学分会肾脏病学组,姚勇,杨霁云,陈述枚,丁洁.小儿肾小球疾病的临床分类、诊断及治疗[J].中华儿科杂志,2001,39(12):746-749. 被引量:1534
  • 9张薇,罗运九,何威逊,朱光华,任志德.婴幼儿肾病综合征病理分型、免疫功能与激素效应的关系[J].实用儿科临床杂志,2002,17(1):32-33. 被引量:11
  • 10于力,翁志媛,花少栋,张又祥,黄逸辉,卓美瑛,杨小苏.婴幼儿期肾病综合征临床特点分析[J].中国实用儿科杂志,2002,17(9):553-555. 被引量:6

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