慢性肝病和肝癌中HCV核心区三种寡肽抗原的抗体检测

Antibodies Against Three Oligopeptides from Core Region of HCV in Patients with Chronic Liver Diseases and Primary Hepatocellualr Carcinoma

检测１４８例慢性肝病和肝癌患者血清中丙型肝炎病毒（ｈｅｐａｔｉｔｉｓＣｖｉｒｕｓ，ＨＣＶ）核心区３种寡肽抗原（ＣＰ９，ＣＰ１０，ＣＰ１４）的抗体，结果显示其阳性率在慢性迁延型肝炎、慢性活动型肝炎、肝炎肝硬化和原发性肝癌患者中分别为７．７％，２３．１％，２３．５％和１６．３％。在抗体阳性者中８０％以上有乙型肝炎病毒（ｈｅｐａｔｉｔｌｓＢｖｉｒｕｓ，ＨＢＶ）感染证据，提示我国ＨＢＶ和ＨＣＶ重叠感染较为常见。在原发性肝癌中有ＨＢＶ感染指标者９５．９％，仅有ＨＬＶ感染指标者占４．１％，说明迄今ＨＢＶ仍是我国原发性肝癌的主要病毒学病因。

Antibodies against three oligopeptides from the core region of HCV(CP9,CP10,CP14) were detected in 148 patients with chronic liver diseases and primary hepatocellular carcinoma(PHC).The positive rates of these antibodies were 7.7%, 23.1%,23.5% and 16.3% in cases of chronic persistent hepatitis(CPH),chronic active hepatitis(CAH),hepatitis liver cirrhosis(HLC)and PHC respectively. More than 80% of patients positive for antibodies to core peptides of HCV had serological evidence of HBV infection indicating that super-infection of HCV in patients with hepatitis B was relatively common. In PHC group 95.9% of cases had serological markers of HBV infection while only 4.1% had antibodies to core peptides of HCV alone; This finding:snggests that HBV may be the major virological factor accounted for PHC.