小檗碱对实验性脑缺血的改善作用

Protective Effects of Berberine on Cerebral Ischemia in Mice and Rats

小檗碱５、１０、２０ｍｇ／ｋｇ腹腔注射，可显著延长双侧颈总动脉结扎致脑缺血小鼠的存活时间。自颅外阻断大鼠大脑中动脉造成局灶性脑缺血模型，小檗碱２０、４ｍｇ／ｋｇ于术前，能缩小缺血２小时造成的梗塞范围，减轻神经功能障碍。小檗碱４０ｍｇ／ｋｇ能提高大鼠急性脑缺血３０分钟时的血浆，海马及皮层脑组织的超氧化物歧化酶活力，降低丙二醛含量。结果表明，小檗碱对缺血脑组织有保护作用，其机理推测与其抗氧自由基损伤有关。

Berberine(Ber 5,10,20mg/kg.ip)significantiy prolonged the survival time of mice subjected to cerebral ischemia by the occlusion of the bilateral carotid arteries. The mortality of the mice subjected to reperfusion after cerebral ischemia wasreduced by Ber,After acute incomplete cerebral ischemia in rats induced by hypotension coupled with hypoperfusion for 30 min,Ber(40mg/kg.ip)might markedly increase the activities of superoxld dismutase and decrease the concentration of malondialdehyde in plasma,as well as in the brain hippocampus and cortex.In the model of local cerebral infarction of rat produced by middle cerebral ariery occlugion,Ber(20.40mg/kg.ip before the operation)decrease the infarct size and ameliorate neurologic deficits,improve electroencephalogram changes in 2h occlusio of rats.