新型林用除草剂环嗪酮的诱变性观察

Observation on Mutagenesis of Hexazinone ──a New Pestcide

用三种不同遗传终点的短期测试方法检测环嗪酮的致突变作用，Ａｍｅｓ试验是检测基因点突变的微生物回复突变试验，微核试验和初级精母细胞染色体畸变试验分别检测哺乳动物体细胞和生殖细胞的染色体损伤，结果表明这三项诱变试验均为阴性，提示环嗪酮无致突变性。

Three mutagenesis experiments with different mutational targets were carried out. Ames test is to detect gene-mutation, Micronucleus test of bone marrow PCE and chromosomal aberration test of primary spermatocyte of mice are designed to detect the chromosomal damages of body cells and reproduction cells respectively. The result of Ames test was negative. The rates of micronucleus of bone marrow polychromatic erythrocytes and chromosomal aberration of primary spermatocyte did not show any obvious change in comparison with the controls. These results indicate that Hexazinone is not a mutagen.