三种东川芎提取物的抗血小板聚集作用

The Antagonizing effect of the Three Components Extracted from Cnidium Officinale Makino on Platelet Aggregation

为了解东川芎抗血小板聚集的有效成分，进行了如下试验。用东川芎的乙酸提取物，以硅胶柱层析，用正己烷和乙醚不同比例的港媒洗脱得到９—１０Ｃ、１４—１５Ａ、２９—３０Ａ三个抗血小聚集的有效组分．初步实验表明三组分抗血小板聚集作用与川芎嗪相似．用相同方法，用正品种芎提取，亦可得到上述三种组分．说明川芎普遍存在以上三种抗血小板聚集的有效组分．

Abstract Three active components(9-10C,14-15A and 29-30A)were extracted from Cnidium Officinale Makino by ethylether and separated by chromato-graphy on silica Selcolumn.The three componentS did not contain chuan-xiongzine or ferulaic acid which were considered to be the main antiplatelete-aggresation composition.When ADP was used as inducer,thesecomponents exhibited a more effective antagonizing effect on platelet aggragation than aspirin.If collagen was used as inducer, 14-15A and 29-30A could more effectively antagonize platelet aggragation than 9-10C and aspirin.