全反式维甲酸在急性早幼粒细胞白血病治疗中的副反应

THE SIDE EFFECTS OF ALL-TRANS RETINOIC ACID IN THE TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA

全反式维甲酸是由我国首创的诱导分化治疗急性早幼粒细胞白血病获得成功的药物。本文对５２例新诊患者接受该药治疗时发生的副反应进行了观察，重点观察特殊副反应，尤其是易引起早期死亡的白细胞淤滞和维甲酸综合征，并对这些严重并发症作了讨论。

All-trans retinoic acid (ATRA) has been successfully used in differentiation induction therapy for acute promyelocytic leukemia (APL),which was pioneered in China. We observed the side effects,emphatically special side effects,and especially the leukostasis and retinoic acid syndrome that may lead to early death easily,during ATRA treatment in fiftytwo newly diagnosed patients with APL. These serious complications were discussed.