肝癌临床分期与外周血T淋巴细胞亚群的变化

AN ANALYSIS OF T-LYMPHOCYTE SUBSETS IN PERIPHERAL BLOOD AND THE CLASSIFICATION OF HEPATIC CANCER

应用Ｔ细胞亚群单克隆抗体检测了３６例肝癌患者外周血Ｔ淋巴细胞亚群的分布，结合日本肝癌研究会肝癌分期进行分析。正常组ＣＤ３和肝硬化组相比无明显差别，而ＣＤ４、ＣＤ４／ＣＤ８明显下降，ＣＤ８明显上升，各Ｔ细胞亚群变化与肝癌分期相关。提示日本肝癌研究会肝癌分期方案不仅能反映肿癌的发展情况，还可为临床评估患者免疫状态提供参考。

The T-lymphocyte subsets in peripheral blood of 36 cases with hepatic cancer have been analysed by monoclonal antibody and the new classification of hepatic cancer. No significant changes were found in CD3. There is a significant decrease in CD4. CD4/CD8 ratio, increase in CD8. The relationship between changes of CD3, CD4, CD8 were closely related to the new classification. The new classification can not only reflect the tumour's advances, but also provide refcrences for the host immunocompetence.