抗视网膜抗体在视网膜病中的初步研究

A PRELIMINARY STUDY ON ANTIRETINAL ANTIBODIES IN RETINAL DISEASES

应用Ｗｅｓｔｅｒｎ免疫印迹技术测定６６例视网膜病病人抗视网膜抗体，４３例出现阳性反应（６５％）．老年黄斑变性病人血清抗视网膜抗体阳性反应极为显著，明显高于健康老人（Ｐ＜０．０２）；视网膜色素变性、特发性视网膜前膜患者血清也有一定的抗视网膜抗体阳性率；而中心性浆液性视网膜脉络膜病变及急性视网膜坏死抗视网膜抗体反应不明显。本文还讨论了这些抗体所作用的抗原的性质及其在这些疾病中的作用。

Sixty-six patients with retinal diseases and seventeen healthy aged persons were tested for serum autoantibodies against normal human retinal protein by western immunoblot analysis. Forty-threc out of 66 patients showed positive responses, with a rate of 65 per cent. The positive rate of antiretinal antibodies in the patients with age-related macular degeneration was significantly higher than that in the healthy aged (P<0.01). About half or more patients with retinitis pigmentosa and idiopathic preretinal membanes presented positive antiretinal antibodies in their sera but seldom in those with central serous chorioretinopathy and acute retinal necrosis. The nature of retinal antigens, with which the antibodies reacted, along with effects on the various retinal diseascs was also discussed.