人巨细胞病毒与男子不育关系的初步研究

CYTOMEGALOVIRUS AND THE MALE INFERTILITY

本实验应用聚合酶链反应(PCR)技术,对63名不育男子的精液进行了HCMV-DNA检测,发现其中5名男子的精液呈HCMV-DNA阳性,阳性率为7.7％。在这5名男子中,有3名男子的精子WGA/IB检测均呈阳性。另外,我们对63名不育男子的精子计数、活动率、畸型率,精液pH值和白细胞数量等指标进行了观察,发现在HCMV感染者与未感染者之间除了精子计数、白细胞数量略有差别外,其它指标无明显区别。因此我们认为男子生殖道HCMV感染,可能会导致不育,其机理是复杂的,而精子数量减少,精子抗体的产生也许是因素之一。

Five positive reactions of HCMV-DNA were detected in semens of 63 infertile men by polymerase chain reaction (PCR)technique. In the semen of these 5 infertile men,3 were positive in WGA and IB detection. In addition, the comparison of the sperm count, sperm motility rate,deformation rate, pH value and the number of leucocyte in the semens showed no difference between the men infected by HCMV and the other infertile men except the slight reduction of the sperm count and the increased number of leucocyte. This study sggests that HCMV might cause the male infertility, the reduction of the sperm count and the appearnce of antisperm antibody may be the factors involved.