GST－π在食管癌及癌前病变组织中的表达意义

EXPRESSION SIGNIFICANCE OF GST-πIN ESOPHAGEAL CARCINOMA AND PRECANCEROUS LESSION

用人体胎盘型谷胱甘肽－Ｓ转移酶（ＧＳＴ－π）抗体，按ＡＢＣ免疫组织化学技术，检测了５０例食管癌、６８例癌前病变组织和５１例正常对照组织。结果表明：正常食管组织ＧＳＴ－π阳性率为３．９％；不典型增生组织为７７．９％；食管癌组织为８６．０％。不典型增生组织中ＧＳＴ－π阳性率随不典型增生程度增著而增加。同此可见，ＧＳＴ－π在食管癌及癌前病变组织中的表达为研究其发病机理和早期诊断提供了新的酶学指标，可以作为食管癌早期诊断的标志酶之一。

In this study, 50 esophageal carcinoma (EC), 68 dysplasia and 51 normal tissue of esophagus with the methods of immunohistochemical stains(ABC)of placental form glutathione S-tranferase(GST-π).The result indicated: in normal tissue, dysplasia tissue and tumor tissue,the positive rates of GST-π were 3. 9%, 77. 9% and 86. 0% respectively.In the tissue adjacent to carcinoma,the positive rates of GST-π in creased in order of mild dysplasia, moderate and severe dysplasia. The result demonstrated that expression of GST-π in transitional mucosa of EC is a new marker of enzymology for study its pathogenesis and early diagnosis.It is possible that GST-π was one of marker in enzymology as early diagnosis of EC.