大骨节病病区儿童硒代谢平衡的研究

Study on selenium metabolic balance in children from an endemic area of Kashin-Beck disease

本文研究了一个大骨节病病区14例12—14岁儿童三天自然进食条件下的硒代谢平衡,以16例非病区儿童作为对照,结果表明:病区组平均硒摄入量12.44μg/日(范围7.69—16.23),明显低于非病区组的96.63μg/日(范围18.90—226.35μg/日)仅为杨氏提出的最低生理需要量40μg/日的31%。病区组硒表面吸收率为27%,不足非病区组的一半(55%)。病区组血硒含量和尿、粪硒排泄量分别为11ng/ml,1.91和9.04μg/日,明显低于非病区组的68ng/ml,25.40和32.94μg/日。两组尿硒均与硒摄入呈明显正相关。但回归方程不同(病区组 r=0.63 (?)=5.6480+3.6540X;非病区组 r=0.72,(?)=32.0757+2.5414X)。病区组硒平衡为+1.43μg/日、与零比较无显著性差异,非病区组+37.88μg/日,与零比较有非常显著性差异。病区有5例(36%),非病区有3例(19%)处于硒负平衡状态,两组比较无显著性差异。硒平衡数据与硒摄入在病区组无显著性正相关而非病区组相关很好(病区组 r=0.1,非病区组 r=0.88)根据回归方程,非病区组需摄入52μg/日的硒维持硒的平衡状态。

Se metabolic balance in 7 male and 7 female children (12-14 years old) froman endemic area of Kashin-Beck disease,consuming self-selected diets was studiedfor three consecutive days,and 16 male children from a non-endemic area wereas control.Mean daily Se intake was 12.44ug with a range of 7.69-16.23ug/dayand was far below 96.63ug/day (rang 18.90-226.35) in control.Mean urinaryand fecal Se outputs were 1.91 and 9.04 ug/day,respectively,comparing 25.44and 32.94ug/day in control.Urinary Se outputs in two groups were significantpositive correlation with daily Se intakes,but there were different regressionequation in two groups (endemic r=0.63,(?)=5.6480+3.6540X;control r=0.72,(?)=32.0757+2.5414X).Mean Se balance during this time was +1.43ug/day andnot correlation with daily Se intake,while it was 37.88ug/day and significantpositive correlation with daily intake (r=0.88) in control.Subject in controlneeded 52ug/day to maintain Se balance depending on regression equation.Meanapparent absorption of Se was 27.11%and far below 55.31% in control.Therewas not any difference between male and female subjects from this endemicarea in Se metabolic balance。