碘油胶丸常用剂量的药物反应观察

An observation on the pharmaceutical reaction of conventional dosage of the iodipin capsule

本文对一次性口服常用剂量碘油胶丸(0.4或0.6克)防治地方性甲状腺肿所出现的药物反应作了观察。服药482人,药物反应发生率为33.82%。反应类型以碘中毒反应为主,变态反应为次,其出现频数分别为81.96%和14.07%。药物反应出现最早的是在服药后5分钟,最迟的在服药后53小时。临床表现主要有头晕、颊部酸痛、咽干、流涕,少数出现眼睑和口唇水肿。大部分无需特殊治疗,能自行好转。同时,对服药前与服药后24、48小时的尿碘作了动态观察。认为:采用小剂量分次服药的方法,可利于机体对碘的吸收、储存和利用,减少浪费;又可避免和减少药物反应的发生。

The pharmaceutic reaction in taking the iodipin capsule once in conventionaldosage for the prevention of endemic goitor was obseved.482 cases took thedrug,the reaction incidence being 33.82%.The main reaction was toxicosis ofiodine,then allergy.Their frequencies were 81.96% and 14.07%,respectively.Theearliest occurrence was in 5 minutes after administration and the latest was in53 hours.The main manifestations were dizzy giddy、cheekache,dry in pharaynx,noserunning,and there were a few cases of eyelid and tip edema.No specialtreatment was needed to these symptoms.Meanwhile a dynamic observation was made on the urinary iodine at aninterval of 24 hours and 48 hours pre-administration and after administration.Theobservation suggested that using a small dosage several times was helpful to org-anisms absorption,store-up and utilization,and that drug reaction was reducedto the minimal degree.