紫外线辐射和充氧对体外健康血cAMP、cGMP、β_2mG、IgA和IgG的影响

In Vitro Ultraviolet Irradiated and xygenated Blood; Its Forthcoming Influence on plasma cAMP,cGMP,β2mG,IgA and IgG

为研究紫外线辐射和充氧对体外健康血ｃＡＭＰ、ｃＧＭＰ、β２微球蛋白（β２ｍＧ）、ＩｇＡ和ＩｇＧ的影响，用放射免疫法测定了健康血紫外线辐射和充氧前后（各４４份标本）血浆中上述物质的含量。结果，紫外线辐射和充氧前后比较，血浆ｃＡＭＰ±１７．２（１３．５５±５．１７对３８．９５ｎｍｏＩ／Ｌ，Ｐ＜０．０１）和ＣＧＭＰ（２．７９±１．４３对３．３７±１．１７ｎｍｏｌ／Ｌ，Ｐ＜０．０５）明显升高，ＩｇＡ则明显降低对（１．３２±０．６２对０．８７±０．３５ｇ／Ｌ，Ｐ＜０．０１），β２ｍＧ和ＩｇＧ均无明显变化（Ｐ＞０．０５），血型Ｏ、Ａ、Ｂ和ＡＢ之间上述血浆物质的变化，无明显差异。提示紫外线辐射和充氧可影响体外血浆ｃＡＭＰ、ｃＧＭＰ和ＩｇＧ水平，这为该方法的临床应用提供了依据。

In order to destermine if ultraviolet irradiated&oxygenated blood affects the plasma values of cAMP,cGMP,β2mG,IgA&IgG in healthy blood in vitro,the above plasma values of cAMP et al were assayed by radioimmunoassay before & after ultraviolet irradiation(times before &after wards ).Following ultravio-let,the plasma values of cAMP(38.95±17.20 vs 13.55±5.17nmol/L,P<0.01);cGMP(3.37 ±1.17 vs2.79±1.43nmol/L,P<0.05)were higher,and IgA(0.87±0.35 vs 1.32± 0.62g/L,P<0.01)was lower;there were no marked changes in β2 mG&IgG. The changes of above cited plasma values in group O blood were not markedly different from those in group A,B or AB. The above data showed that ultravio-let blood affects quite a number of the var-ious above cited plasma levels,offering a theoretical basis for its clinical applica-tion.