肺癌脑转移26例临床分析

Clinical Assessment of Bronchogenic Carcinoma with Cerebral Metastasis in 26 Cases

从２９８例肺癌患者资料中，收集到有脑部转移者２６例，分析临床首发症状、脑间转移灶数目、病理类型，及治疗方式四个因素与生存期的关系。结果表明，肺鳞癌及腺癌脑转移的生存期较之小细胞肺癌脑转移长。采取综合治疗（肺内或脑转移灶切除，配合术后放疗及化疗）比单一非手术治疗生存期长。颅内脑转移灶数目对生存期的影响在本组资料中单发脑转移、多发脑转移生存期在两组间无明显差异。而首发症是以肺内为首发，或与脑部症状为首发生存期在二者间也无显著性差异。从而说明，肺癌本身预后很差，给予原发灶手术切除及转移灶切除或放疗可望延长生存期及生存质量。

The article colleced 26 cerebral metastatic cases from 298 lung cancer patients and assessed first symp-tom,number of cerebral metastases,histo-logic types and treatment modility,four factors that is relative to survival.The re-sults showed that the survival was longer in squamous carcinoma and adenocarcino-ma than that in small cell lung cancer. Multimodality therapy(including primary and metastatic tumor resection,followed by chemotherapy or radiation )was superi-or to non-surgical resection. There was no significant difference in survival between solitary and multiple brain metastases. Furthermore , the survival in patients withcerebral metastases as first symptom did not differ from the patients with lung can-cer as first sympton. That means the over all lung cancer population has a poor prog-nosis,specially with brain metastases. The surgical resection to primary and ,or metastasis as well as post-operative adju-vant radiation may prolong life and opti-mize the quality of life.