口服红霉素治疗胃瘫的实验研究

Gastrointestinal motility increases after oral administration of erythromycin

实验犬8条,每次令口服一种大环内酯类抗生素,并记录其肠道动力。结果发现口服红霉素和静脉给药同样能明显增加小肠动力。两种红霉素制剂,红霉素硬脂酸和红霉素硷,都具增加小肠动力的功效;而另外两种大环内酯类抗生素,交沙霉素和螺旋霉素,却无明显的促进胃肠动力的作用。

Gastroparesis is a common complication seen after abdominal operations.Intravenous administration of ery- thromycin has been reported to be effective in treatment of gastroparesis.This study used 8 dogs to see if oral ad- ministration of erythromycin has similar effect.The re- sults showed that both erythromycin stearate and ery- thromycin base increased intestinal motility.However, other 2 macrolides,josamycin and spiramycin had no such effects.