缺血性中风血浆β血小板球蛋白及血小板因子4的动态观察

CONSECUTIVE OBSERVATION OF PLASMA β-THROMBOGLOLBULIN AND PLATELET FACTOR 4 IN ISCHEMIC STROKE

应用ＥＬＩＳＡ法对３２例缺血性中风病人的β血小板球蛋白（β－ＴＧ）和血小板因子４（ＰＦ４）的血浆浓度进行了动态观察，并与２０例健康对照组比较。结果表明，ＴＩＡ组病人的ＰＦ４血浆浓度较对照组明显升高，差异有显著性（Ｐ＜０．０５），β－ＴＧ无明显变化。脑血栓组在其发病后７６以内、７～２０ｄ及３０ｄ以上３个不同时期内，其β－ＴＧ及ＰＦ４血浆浓度均高于对照组，差异有显著性（Ｐ＜０．０５）。提示血小板活性增加参与了缺血性脑血管病的发生和发展。

The plasma concentrations of β-thromboglobulin(β-TG) and platelet factor 4(PF4)were measured in 32 patients with ischemic cerebrovascular disease(ICVD) and 20 normal subjects.It was found that the plasma β-TG and PF4 concentrations were significantly elevated in the acute and chronic phases of cerebral thrombosis as compared with those in the controls(P<0.05).Plasma PF4,not β-TG,was higher in TIA patients than in the controls(P<0.05),This result suggests that the increase of platelet activity is involved in the development of ICVD.