门脉性肝硬变病人脾切除后外周血T淋巴细胞亚群的变化

CHANGES IN SUBSETS OF LYMPHOCYTES IN LIVER CIRRHOSIS PATIENTS AFTER SPLENECTOMY

采用间接免疫荧光法测定门脉性肝硬变病人脾切除前后外周血Ｔ淋巴细胞亚群的变化，同时测定血清免疫球蛋白。结果表明，门脉性肝硬变病人外周血Ｔ淋巴细胞亚群及其分布是正常的，血清免疫球蛋白ＩｇＧ升高。脾切除后外周血总Ｔ淋巴细胞和辅助细胞（Ｔｈ）降低，抑制细胞（Ｔｓ）升高，Ｔｈ／Ｔｓ比值下降；血清免疫球蛋白ＩｇＭ降低。提示机体的细胞免疫和体液免疫都有紊乱。

We measured the changes in the subsets of lymphocytes in the peripheral blood as well as the serum immunoglobulin in patients with liver cirrhosis. The results showed that the subsets of lymphocytes and their distribution in the patients were normal, but the serum immunoglobulin IgG was higher in the patients than in the controls(P< 0.05 ).After splenectomy the total T cells(T3)and the T helper cells(Th)decreased significantly(P< 0.01),but the T suppressor cells(Ts)increased remarkably(P<0.05).The Th/Ts cells ratio decreased(P<0.05).Th patients serum immunoglobulin IgM was obviously lower than before the operation(P<0. 05), The results indicate that after spleneatomy the patients'immune function was disturbed.