肺鳞癌BSL受体的表达与临床病理的关系

STUDY OF RELATION BETWEEN EXPRESSION OF BSL RECEPTOR AND CLINICAL PATHOLOGY OF LUNG SQUAMOUS CARCINOMA

应用亲合组织化学方法对９２例原发性肺鳞癌西非单叶豆（ＢＳＬ）受体的表达进行了临床病理学研究。结果发现，ＢＳＬ受体在肺鳞癌中的质膜阳性率高于胞浆阳性率（Ｐ＜０．０５）。质膜阳性率在鳞癌的不同组织学分级之间差异有显著性（Ｐ＜０．０５），随鳞癌分级的增加，质膜阳性率降低。ＢＳＬ受体全细胞阴性表达率在有、无肺门淋巴结转移两组间差异有显著性（Ｐ＜０．０５），ＢＳＬ受体质膜阳性率及细胞全阴性率在生存期不同病人间差异有显著性（Ｐ＜０．０５，Ｐ＜０．０２５）。提示ＢＳＬ受体对肺鳞癌有相对特异性，与肺鳞癌临床病理的生物学行为有一定的关系。

The relation between the expression of the BSL receptor and the features of clinical pathology in 92 cases of lung squamous carcinoma was studied with affinitive histochemistry,The results showed that the positive rate of BSL-R in lung squamous carcinoma was 68.48.The expression of BSL-R on the plasma membranes was higher than that in the intraplasma(P<0.05).The positive rate of BSL-R on the membranes were different among different squamous carcinoma gradings(P<0.05).They decreased with the increase of histopathological gradings;The negative rate of BSL-R was also different between node-positive and node-negative groups(P<0.05).Among the patients in the two groups with different survival times,the positive rate on plasma membranes was obviously different(P<0.05) and so was the negative rate(P<0.025).The indication is that the BSL-R has relative specificity for human squamours carcinoma.It is somehow related to the biological behaviours of lung squamous carcinoma in clinical pathology.