非胰岛素依赖型糖尿病病人红细胞镁浓度变化及镁对红细胞变形能力的影响

CHANGES OF ERYTHROCYTE MAGNESIUM CONCENTRATION IN PATIENTS WITH NON-INSULIN DEPENDENT DIABETES MELLITUS AND EFFECT OF MAGNESIUM ON ERYTHROCYTE DEFORMABILITY

检测了６４例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）病人红细胞镁（Ｅ－Ｍｇ（２＋））浓度变化，同时观察了镁在体外对ＮＩＤＤＭ病人红细胞变形能力（ＥＤ）、红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶活性、Ｅ－Ｍｇ（２＋）和红细胞钙（Ｅ－Ｃａ（２＋））浓度的影响。结果显示，ＮＩＤＤＭ病ＨＥ－Ｍｇ（２＋）浓度较对照组明显降低（Ｐ＜０．００１），有血管病变者降低更明显。ＮＩＤＤＭ病人红细胞与镁共同孵育后，红细胞滤过指数（ＩＦ）、Ｅ－Ｃａ（２＋）明显降低，Ｅ－Ｍｇ（２＋）和红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶活性明显增高，与孵育前比较差异有极显著性（Ｐ＜０．００１），与对照组比较差异无显著性（Ｐ＞０．０５）。提示镁对改善ＮＩＤＤＭ病人血液流变学、减少血管病变的发生有重要意义。

The concentration of erythrocyte magnesium(E-Mg(2+) was measured in patients with non-insulin dependent diabetes mellitus(NIDDM),and the effect of magnesium on the erythrocyte deformability(ED), erythrocyte membrane Na+-K+-ATPase activity and the concentration of erythrocyte calcium (E-Ca(2+) in patients were observed in vitro.The results showed that the concentration of E-Mg(2+)was significantly lower in patients than in the controls(P<0.001).The abnormalities of E-Mg(2+)in patients with vascular lesions was more obvious than those in patients without vascular lesions.After the patients,erythrocyte was incubated with magnesium,the E-Mg(2+)concentration and Na+-K+-ATPase activity was significantly higher and E-Ca(2+) concentration and erythrocyte filtration index(IF)significantly lower,as compared with the group before the incubation(P<0.001).These results indicate that magnesium is more effective in improving the blood rheology and reducing the occurrance of vascular lesions in patients with NIDDM.