大鼠下丘脑注射神经降压素在孤束核压力感受性反射中的作用

THE ROLE OF NEUROTENSIN IN HYPOTHALAMUS ON NUCLEUS OF TRACTUS SOLITARIUS BARORECEPTOR REFLEX IN RATS

采用电解损毁核团及脑区微量注射方法，探讨孤束核在下丘脑前部减压区注射神经降压素对静脉注射新福林兴奋压力感受性反射中的作用。结果表明，①电解损毁弧束核后，新福林升压效应显著升高（Ｐ＜０．０１）；②电解损毁孤束核后，下丘脑前部减压区注射神经降压素，新福林升压效应无显著改变（Ｐ＞０．０５）。提示神经降压素在下丘脑前部减压区易化压力感受性反射作用可能主要通过孤束核而实现的。

The effect of the nucleus of the tractus solitarius (NTS)on the pressor response of intravenously administered phenylephrine after microinjecting neurotensin(NT)into the anterior hypathalamic area(AHA),was studied by means of destroying the nucleus by electrolytic process and microinjecting into the brain,The results were as follows∶1)The pressor response of phenylephrine was significantly intensified after electrolytic process destroyed the NTS(P<0.01).2) After the electrolytic process destroyed the NTS,the pressor response of phenylephrine disappeared on microinjecting NT into the AHA(P>0.05).The results indicate that NT's facilitating baroreceptor reflex in the AHA may be related to NTS.