γ－环糊精－SDS胶束电动色谱法分离十八甲基炔诺酮光学异构体

Cyclodextrin-Modlfied Sodium Dodecyl Sulfate MicelarEIectrokinetic Chromatography Separation of NorgestreI Enantiomer

研究了ＣＤ－ＳＤＳ胶束电动色谱（ＣＤ－ＭＥＫＣ）对电中性及疏水性的手性化合物的分离，并讨论了不同类型ＣＤ的手性识别作用。使用γ－ＣＤ可以有效地拆分十八甲基块诺酮（ＮＯＧ）旋光异构体。选择了最佳分离条件，通过调节ＣＤ和ＳＤＳ浓度以及其它操作条件可以把ＮＯＧ异构体很好的分离。

yclodextrin-modified sodium dodecyl sulfate micellar electrokinetic chromatography was applied to theseparation of neutral and hydrophobic chiral compounds. The chiral recognition of different cyclodextrin wasalso discussed.Norgestrel enantiomers were successfully separated with γ-cyclodextrin. The separation can6optimlzed by changing cyclodextrin,sodium dodecyl sulfate concentration and other operatiotig parame- ters.