乳腺癌ER、PgR与CEA及组织病理关系的研究

Relationship between ER,PgR and CEA,and histopathological features inhuman breast cancer

本文应用ＰＡＰ免疫组化法检测８０例乳腺癌的ＥＲ、ＰｇＲ与ＣＥＡ，乳腺癌ＥＲ和ＰｇＲ呈高度正相关，但并不完全一致，因此应同时检测乳腺癌的ＥＲ和ＰｇＲ，以便提高其内分泌治疗的有效率。实验结果还表明，ＥＲ及ＰｇＲ阳性率与乳腺癌分化程度有关，分化越好ＥＲ和ＰｇＲ的阳性率越高，但ＥＲ和ＰｇＲ的表达与组织学类型、肿瘤大小及淋巴结转移情况无明显关系。ＣＥＡ是乳腺癌的生物学标记之一，已有文献报道ＣＥＡ阳性是预后不良的指征，本实验结果表明，ＥＲ和ＰｇＲ阳性乳腺癌ＣＥＡ多为阴性，因此在检测ＥＲ、ＰｇＲ的同时检测ＣＥＡ可更准确地预示病人的预后。

he relationship between estrogen receptor(ER),progesteronereceptor(PgR)and carcinoembryonic antigen(CEA) in 80 cases of humanbreast cancer was studied by using PAP immunohistochemical method,Theresults showed that expression of ER and PgR in breast cancer was posi-tive correlation,but extent was difference,We thought that the simultane-ous assay of ER and PgR was more helpful to increase the effectivenessof endocrinotherapy,The positive rates of ER and PgR in well-differenti-ated carcinomas were higher frequently than those of poorly differentiatedtumours( P<0.025,P<0.025),t was not found that the hormone receptorswere related to histological type, size of tumor and lymphatic metastasis( P>0.5,0.9 P>0.1,0.9, P>0.5,0.1),CEA was one of the biologicalindexes of breast cancer, and positive CEA was a sign of poor prognosis。Our results showed that in most of breast cancer patients with positiveER and PgR,CEA was negative。Therefore,when ER and PgR were examined,the determination of CEA could predict the prognosis of the patients。