几种新抗疟药联合应用治疗海南省恶性疟的效果观察

OBSERVATION ON THE EFFICACY OF COMBINED USE OF SOME NEW ANTIMALARIALS FOR THE TREATMENT OF FALCIPARUM MALARIA IN HAINAN PROVINCE

1985～1987年6～10月连续3年在海南省三亚市和乐东县抗氯喹恶性疟流行区用喹哌750mg+硝喹25mg联合用药治疗33例恶性疟患者,其平均退热时数为39h;原虫无性体平均转阴为49h。服药后28d的复燃率在不同地区为0～47％。 用咯萘啶600mg+硝喹25mg治疗11例;咯萘啶800mg+硝喹40mg治疗43例;咯萘啶800mg+硝喹80mg治疗31例,其退热时数为31～35h,原虫无性体平均转阴为46～53h,服药后28d的复燃率在13～18％之间,与对照组单服咯萘啶1200mg治疗42例的平均退热时数33h,平均原虫无性体转阴时数48h和28d复燃率12％无显著性差别。各组服药前后曾抽样进行了血、尿常规、肝功能等检查,结果都在正常范围之内,证明联合用药是安全的。

Field trials were carried out to assess the therapeutic effects including the combined use of piperaquine (PQ) with nitroquine (NQ) and pyronaridine (PYR) with NQ against falciparunt malaria in regions of Hainan Province with chloroquine-resistance in 3 successive autumns from 1985 to 1987.In an evaluation of PQ 750mg with NQ 25mg therapy in 33 falciparum malaria patients, the average fever subsidence time and parasite clearance time were 39 hours and 49 hours respectively, but within 28 days after medication, the recrudescence rates were 0-47% in different regions.In evaluations of PYR 600 mg with NQ 25 mg in 11 cases, PYR 800 mg with NQ 40 mg in 43 cases, PYR 800 mg with NQ 80 mg in 31 cases, the fever subsidence time were 31-35 hours, the parasite clearance time were 46-53 hours and the 28 days recrudescence rates were 13 - 18 %. In the control, the use of PYR 1200 mg alone in 42 cases, the average fever subsidence time and parasite clearance time were 33 hours and 48 hours respectively, the 28 days recrudescence rate was 12%. There was no statistically significant difference among them in their effects. The side-effects of all groups were mild.