丙二酸与光活性脂环酮的成环反应研究

Studies on the cyclization reaction between malonic acid and optically active aliphatic cyclic ketones

在乙酸酐和少量硫酸存在下，丙二酸与具光学活性脂环酮反应缩合成Ｍｅｌｄｒｕｍ酸的类似物．除（－）－薄荷酮生成相应产物产率可达３２％外，（Ｒ）－（十）－樟脑、（Ｓ）－（－）－樟脑和（Ｒ）－葑酮的反应产率仅有１～２％．（Ｒ）－诺蒎酮在这反应条件下发生重排反应，生成丙二酸（４’－亚异两基）亚环己酯，产率为３３％．

In the presence of acetic anhydride and a small amount of sulphuric acid, the condensation reaction between malonic acid and optically active aliphatic cyclic ketones gave Meldrum'S acid analogues. (-)-Menthone changed to its corresponding product in 32% yield, while (R) - (+) -camphor (S) - (-)-camphor and (R)-fenchone turned to their corresponding products only in 1- 2% yield. In the same reaction condition,(R)-Nopinone rearranged into (4'-isopropylidene ) cyclohexylidene malonate in 33%yield.