大肠癌及其癌前病变AgNORs的研究

AgNORs Study of Colorectal Cancer and Precancerous Lesions

应用自动图象分析仪，对６５例大肠癌和伴不同程度不典型增生的大肠腺瘤以及正常肠粘膜的标本，进行了ＡｇＮＯＲｓ颗粒数和颗粒面积的测定和分析。结果显示：核中平均ＡｇＮＯＲｓ颗粒数随细胞异型性的加重逐渐增加，各病变间的差异有显著意义（Ｐ＜０．０１）。ＡｇＮＯＲｓ颗粒面积逐渐减小，正常肠粘膜，轻、中度不典型增生分别和重度不典型增生及癌有显著差异（Ｐ＜０．０１）。研究认为：ＡｇＮＯＲｓ测定可作为大肠癌及其癌前病变的客观诊断指标，大肠重度不典型增生和癌有较多相似特性，临床上对此病变要高度警惕。

Specimens taken from the normal mucosa,adenoma associated with varied degrees of dysplasia and colorectal adenocarcinoma 65 cases were submitted to AgNORs stuey with an automatic image analysis system.Results showed that the mean number of AgNORs per nucleus increased with exaggeration of cell atypia,while the mean area per AgNORs granule decreased.Differences between different groups were statistically significant (P<0.01).We concluded that the measurement of AgNORs can act as an objective diag nostic criteria to colorectal tumours and severe dysplasia has close resemblance to cancer,suggesting precantions should be paid.