急性白血病药物治疗后红细胞生成素的改变

Erythropoietin Variation in Acute Leukemia Before and After Intensive Cytostatic Draugs

对４３例急性白血病患者细胞毒药物治疗前后的红细胞生成素（ＥＰＯ）进行观察，并与正常人组、其他贫血组进行对照。发现急性白血病化疗前ＥＰＯ水平高于正常人（Ｐ＜０．０１），但低于同等程度贫血的其他疾病组（Ｐ＜０．０１）。化疗后在Ｈｂ无明显改变的情况下，ＥＰＯ水平急剧增高，显著高于化疗前水平（Ｐ＜０．０１）。骨髓抑制严重者ＥＰＯ上升幅度大。细胞毒药物引起ＥＰＯ水平异常增高的原因尚不清楚，骨髓受抑制ＥＰＯ消耗减少，细胞毒药物通过某些机制使ＥＰＯ活性增加或刺激ＥＰＯ合成，为可能的因素。

Serum erythropoietin(EPO)was measured in 43 patients with acute leukemia before and after intensive chemotherapy. The EPO levels in acute leukemia was higher than that in the control normal population(P<0.01)and lower than th at in other diseased patients with anaemia(P<o.01)before chemotherapy. In all patients with leakemia EPO markedly increased after initiation of treatment,although the hemoglobin concentration remained at stable values. Subsequently the EPO returned to baseline levels after 3 weeks even in patients who were anaemic at the ture. The explanation for this inappropriate increase in EPO is not clear. The possible explanation for elevated levels is that they are caused by decreased consumption from suppression of the marrow,or by cytostatic treatment which stimulated EPO synthesis via a hitherto unknow mechanism.