肾移植患者尿白蛋白、IgG、IgA、IgM排泄率及清除率变化

Urinary Excretion and Clearance Rates of Albumin and Immunoglobulins in Patients with Kidney Transplantation, Essential Hypertension and Normal Controls

对肾移植患者３２例、原发性高血压患者１２０例、正常人８０例三组人群进行精确定量法测定尿ＩｇＧ、ＩｇＡ、ＩｇＭ及白蛋白（Ａｌｂ）的２４ｈ排泄率和清除率，发现肾移植患者２４ｈ排泄率和清除率明显高于高血压组和正常人组（Ｐ＜０．０１～０．００１）。认为ＩｇＧ、ＩｇＡ、ＩｇＭ及Ａｌｂ２４ｈ排泄率和清除率增高，与慢性排异反应、环抱素Ａ（ｃｙｃｌｏｓｐｏｒｉｎＡ，ＣｓＡ）肾毒性有关，可作为排异反应、ＣｓＡ肾毒性早期诊断条件，对临床治疗好转与否有一定指导意义。

Urinary excretion and clearance rates of albumin and IgG, IgA,IgM were determined in 32 patients with kidney transplantation, 120 patients with essential hypertension and 80 normal controls.These excretion and clearance rates were significantly higher in patients with kidney transplantation than in patients with essential hyperension and normal controls; It is assumed that these elevations may be related to and can be used for the detection of graft rejection and toxicity of cyclosporin A.