纤维连接蛋白在肾脏疾病中变化的意义

Changes in Fibronectin in Renal Diseases

测２０例尿毒症患者血浆纤维连接蛋白（Ｆｎ）含量，证实尿毒症患者血浆Ｆｎ降低，并与患者中性粒细胞（ＰＭＮ）吞噬功能低下有关联。体外实验证实Ｆｎ有促进ＰＭＮ吞噬功能作用，且与其浓度正相关。表明血浆Ｆｎ与机体免疫防御功能关系密切，其水平可反映患者细胞吞噬功能状态。测４９例各种病理类型肾小球肾炎患者肾组织内Ｆｎ，发现Ｆｎ在系膜增生型肾炎中增高；在局灶节段或球性硬化型中减少。提示肾内Ｆｎ改变可反映肾小球系膜病变或发展规律，对其监测可能对观察肾小球疾病进展尤其硬化过程具有重要意义。

Plasma fibronectin (Fn) was determined in 20 patients with uremia. A low level of plasma Fn was detected and the level of plasma Fn correlated with deficiency in phagocytosis of polymorphonuclear (PMN); In vitro experiments. Showed that Fn could enhance the phagopcytosis of PMN in a dose-dependant manner. This suggests that there is a close relationship between plasma Fn and immunodefensive function of the body. The level of piasma Fn represents the functional status of PMN. The content of Fn in renal tissue was also determined in 49 patients with various types of glomeruionephritis. Fn was increased in mesangial proliferative glomerulonephritis and decreased in glomerulonephritis with focal segmental glomerular sclerosis or global sclerosis. These data suggest that the content of Fn in the kidney may reflect the stage of mesangial pathogenesis. Determination of Fn in kidney is supposed to be important for observing the progression of glomerular disease, especially the process of slcerosis.