摘要
综述了遗传毒性化学物质与DNA的加合作用,以及DNA加合物形成后在致癌作用中的影响。说明DNA加合物的形成及剂量关系可以作为化学物质致癌能力的指标。比较了DNA加合物检测方法的特点及DNA加合物研究的前景。
Review on combination of genotoxic chemicals with DNA and the effects of DNA adduct formation on carcinogenesis were presented. It was found that the formation of DNA adducts and dose-dependent response could be provided as an index of carcinogenic potential of chemicals. Comparison of the characteristics of methods for detecting DNA adduct and it perspectives were also illustrated.
出处
《上海环境科学》
CAS
CSCD
1995年第7期43-45,共3页
Shanghai Environmental Sciences
关键词
致癌物
致癌作用
接触一效应关系
DNA加合物
Carcinogens Carcinogenesis Exposure-effect radiation DMA repair Reproduce Study Progress DNA adduct
