不同剂量阿米替林维持治疗对于抑郁症预防复发效果的比较

Prevention of recurrent depression with maintenance treatment of amitriptyline: a double blind comparison among different dosaages

将36例反复发作抑郁症病人随机分为A、B、C三组,分别服用175～200mg、125～150mg、75～100mg阿米替林维持治疗,进行3～4年的前瞻性、盲式、对照随访研究。结果显示:A组复发危险性比B组小153%,比C组小188%;4年缓解率A组为60.0%,B组为16.2%,C组为8.6%。提示充分治疗量仍是维持治疗的最佳剂量。

Thirty three cases with recurrent depression were randomly assigned to 3 groups, each taking one of the three different dosage of amitriptyline as maintenance treatment for the prevention of the relapse of depression. The follow-up periods were 3-4 years. The conclusion was: maintenance treatment with original adequate therapeutic dosage showed the best result in prevention of relapse.