恶性症状群的危险因素(附病例对照研究)

The risk factors of Neuroleptic Malignant Syndrome (NMS)

目的 探讨恶性症状群(NMS)的危险因素。方法 以37例NMS病例与同期住院的非恶性症状群病人进行配对比较,按单因素及Logistic回归分析方法进行统计分析。结果 1.单因素分析:长效注射剂、ECT、过度兴奋、营养不良等4项有显著差异;2.Logstic回归分析:ECT对NMS有负效应。结论 NMS的发生与药物、精神及躯体因素有关;ECT有可能预防NMS的发生。

Object The risk factors of NMS were studied. Methods The information of 37 cases of NMS and 37 cases of non-NMS psychiatric patients (as control) were analyzed with Logistic regression statistical method. Results 1. Single factor analysis: There were significant differences between NMS/and non-NMS in injection of depot neurolepties, ECT, hyperexcitation, and malnutrition between NMS and non-NMS. 2. Logistic regression analysis: ECT had negative effect on NMS. Conclusion The development of NMS was related to medication, mental status, and somatic status, ECT might have some advantages in the prevention of NMS.