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国产硫利哒嗪和氯氮平治疗精神分裂症双盲对照研究

Thioridazine in the treatment of schizophrenia: a double-blind controlled clinical trial compared with clozapine
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摘要 目的 探讨硫利哒嗪(甲硫哒嗪)治疗精神分裂症阴性、阳性症状的疗效和副反应。方法 按双盲方式以硫利哒嗪和氯氮平治疗精神分裂症各20例,用BPRS、SAPS、SANS观察疗效,以TESS记录副反应。用方差分析、t检验、卡方检验和Ridit检验进行分析比较。结果 两组疗效相当,副反应有所不同,硫利哒嗪的副反应较轻微。 Object The efficacy and side effects of local made thioridazine in schizophrenic patients were studied. Methods 20 schizophrenic patients were treated with thioridazine and another 20 cases with clozapine according to double-blind principle. The efficacy were evaluated with BPRS, SAPS, and SANS, and the side effects were assessed with TESS. The results were analyzed with ANOVA, t test, Chi-square test, and Ridit test. Results The efficacies of these two group were similar, but the side effects of thioridazine were lesser than that of clozapine.
出处 《上海精神医学》 1995年第4期253-255,282,共3页 Shanghai Archives of Psychiatry
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