油酸多相脂质体（139）对小鼠腹腔巨噬细胞产生TNF及脾脏NK细胞活性的影响

The Influence of Oleic Acid Polyphase Liposomes (139) on TNF Production of Mouse Macrophages and on NKActivity of Mouse Splenocytes

本工作证明，油酸多相脂质体（１３９）能显著促进ＭΦ产生ＴＮＦ，同时对脾脏ＮＫ活性也有提高作用。此外，在荷瘤鼠ＮＫ活性低于正常鼠的情况下，腹腔注射１３９可在一定程度上提高荷瘤鼠的ＮＫ活性。据此推论，活化ＭΦ是１３９主要的抗肿瘤途径。

Oleic acid polyphase liposomes (139), prepared from our laboratory, was poved to be an immunomodulating drug with antitumor activity in our past study. In the present investigation, we have examined its effect on TNF production of mouse peritoneal macrophges and NK activity of mouse splenocytes. The results demostrated that 139 could promptly improve the production of TNF by macrophages. 139 was also effective in augmenting NK activity. This effect was obvious in normal mice.However, the increase of NK actvity was not statistically significant due to individual difference between S180-bearing mice. Byt this judgement, the authors consider that activation of macrophages is probably the main route of anticancer action of 139.