胸膜渗液中IFN-γ、IL-2及NKCF活性的研究

Study on IFN-γ,IL-2 and NKCF Activity in Pleural Effussion

有实验证明，结核性胸膜炎是研究局部细胞免疫的一个很好模型。因在结核性胸膜液中有多种免疫细胞聚集，势必也含有许多与免疫有关的细胞因子。本文对１４例结核性胸膜炎及１２例肿瘤性胸腔积液病人胸膜渗液中的细胞免疫成分进行了研究。测定其主要细胞因子的含量，以比较迟发型变态反应性的结核性胸水与免疫反应减弱的肿瘤性胸水中细胞因子含量的异同，进一步阐明两种疾病局部免疫的不同机制。我们所研究的细胞因子有γ-干扰素（ＩＦＮ-γ）、白细胞介素２（ＩＬ-２）和自然杀伤细胞毒因子（ＮＫＣＦ）。结果显示：结核性胸膜液中ＩＦＮ-γ、ＩＬ-２及ＮＫＣＦ活性均比肿瘤性渗液为高，以ＩＦＮ-γ含量为最高。

Tuberculous pleurisy is a good model for resolution of local cellular immunity.It should be noted that tuberculous pleural effussion contains a variety of cytokines because of the accumulation of many immunocompetent cells in the pleural cavity.In this research paper,the activities of IFN-γ,IL-2 and NKCF were investigated in 14 patients with tuberculous pleural effussion and 12 patients with malignant pleural effussion.We assayed the levels of main cytokines and compared the differences of cytokine contents in pleural effussion between patients with tuberculosis and patients with malignant diseases.Experimental results show that IFN-γ,IL-2and NKCF are higher in tuberculous pleural effussion than in carcinomatous pleural effussion.