杏仁内侧核微量注射AVP和AVPMcAb对兔ET性发热效应的影响

Effect of Microinjection of AVP and AVPMcAb into Medial Amygdaloid Nucleus on Endotoxin-induced Fever in Rabbits

在杏仁内侧核微量注射精氨酸加压素（ＡＶＰ）和精氨酸加压素单克隆抗体（ＡＶＰＭｃ－Ａｂ），观察其对兔内毒素（ＥＴ）性发热效应的影响。结果表明，杏仁内侧核微量注射ＡＶＰ能明显抑制兔ＥＴ性发热效应，注射ＡＶＰＭｃＡｂ则能明显提高兔ＥＴ性发热效应；而将ＡＶＰ和ＡＶＰＭＣＡｂ注射到杏仁外侧核则对兔ＥＴ性发热效应无明显影响。提示：杏仁内侧核也是ＡＶＰ抗热作用的一个重要作用部位。

The experiments were undertaken to investigate the effects of microinjection ofarginine vasopressin (AVP) and arginine vasopressin monoclonal antibody(AVPMcAb)into the medial amygdaloid nucleus (meA) on endotoxin-induced fever in rabbits.The results were as follows: ①Injection of AVP into meA markedly suppressed endotoxin-induced fever. Injection of AVPMcAb into meA markedly augmented andprolonged fever responses. ②Injection of AVP or AVPMcAb alone into lateral amygdaloid nucleus did not influence febrile responses. These results provided evidencesthat AVP might act within the meA to evoke antipyresis.