乙型肝炎病毒X抗原在小儿原发性肝癌中的表达

THE EXPRESSION OF HBxAg IN PRIMARY LIVER CARCINOMA IN CHILDREN

采用免疫组织化学方法检测标本中8例小儿原发性肝癌的乙型肝炎病毒表面抗原(HBsAg)、核心抗原(HBcAg)、e抗原(HBeAg)及x抗原(HBxAg)的表达,发现标记物中,HBxAg与HBsAg、HBcAg、HBeAg出现率均较高(HDxAg、5/8),表明x抗原与乙型肝炎中的上述抗原伴随出现,提示乙型肝炎病毒感染与小儿原发性肝癌有关。

The expression of HBsAg, HBcAg and HBxAg in 8 cases of primary liver carcinoma in children were assayed by immunohistochemistry method. The results sbowed that the detective rate of HBxAg, HBsAg, HBcAg and HBeAg were high (HI xAg 5/8). The association between the aforementioned antigen with X antigen and hepatitis B was revealed, suggesting that HBV infection was related to primary liver carcinoma The relationship between X gene and liver cell carcinoma was also discussed.