摘要
用蛋白水解酶抑制剂α２巨球蛋白（α２Ｍ）研究它对肿瘤生长的影响。离体实验中证实它能抑制胃腺癌 ＳＧＣ－７９０１的迁移。整体实验中它能抑制 Ｌｅｗｉｓ肺癌细胞的生长和肺部转移，抑制效应与剂量相关。合并阿霉素（ＡＤＲ）应用，抑制效果更为显著。同时，发现移植Ｌｅｗｉｓ肺癌细胞的小鼠经α２Ｍ、ＡＤＲ或α２Ｍ合并ＡＤＲ治疗后，其血浆组织蛋白酶Ｄ活性降低，而红细胞中超氧化物歧化酶水平升高。表明α２Ｍ的抑癌效果不单纯是抑制蛋白酶的结果。
The antitumor activity of α2-macroglobulin (α2M) was investigated in vitro and in vivo. α2M was found to be an inhibitor of tumor growth. This study demonstrated that α2M inhibited migration of SGC-7901 gastric adenocarcinoma cells, in vitro. In mice with transplantation of Lenis lung carcinoma colls, α2M showed dose-dependent antimetastatic activity. The combination of α2M and adriamycin revealed significantly greater antimetastatic activity than that of each agent used alone. The results of investigation on α2M treated mice with transplantation of Lewis lung cacinoma showed decreased activity of cathepsin D in plasma but a rising level of SOD in erythrocytes.
出处
《上海医科大学学报》
CSCD
1995年第2期85-88,共4页
Journal of Fudan University(Medical Science)
基金
国家自然科学基金!(38970819)资助
